Professor Jemma C. Hopewell
Websites
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CTSU
Senior Scientist in Genetic Epidemiology and Clinical Trials, Clinical Trials Genetics Programme Lead
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Big Data Institute
Group Leader
- British Heart Foundation
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BHF Centre of Research Excellence
Principle Investigator
- HPS2 -THRIVE: Treatment of HDL to Reduce the Incidence of Vascular Events
- HPS3 / TIMI 55 - REVEAL : Randomised EValuation of the Effects of Anacetrapib through Lipid-modification
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PROCARDIS
Co-PI
- MRC/BHF Heart Protection Study
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CARDIoGRAMplusC4D
Steering Committee; Co-chair
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International Stroke Genetics Consortium
Steering Committee, Chair of METASTROKE
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Stroke
Editorial Board
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PLOS ONE
Guest Editor
Jemma Hopewell
BSc (Hons) MSc PhD (Cantab) FESC
Professor of Precision Medicine & Epidemiology
- MSc in Global Health Science Module Lead: Genetic Epidemiology
- EPSRC Centre for Doctoral Training in Health Data Science Module Lead: Genetics
- Visiting Professor & Affiliate, Department of Human Genetics, McGill University
- NIHR Oxford BRC, Cardiovascular Theme, Co-lead "Identifying and validating new therapeutic targets" subtheme
Interests: Cardiovascular Disease, Arrhythmias, Risk Factors, Clinical Trials, Epidemiology, Genetic Epidemiology, Pharmacogenetics
Professor Jemma Hopewell leads a team of genetic epidemiologists, clinical fellows, medical statisticians and bioinformaticians in a programme of research focusing on the use of genetic and clinical trial-based studies to investigate the causes and treatments for cardiovascular disease and arrhythmias. She has particular interests in using epidemiological, genetic and other large-scale 'omic approaches to improve our understanding of drug targets and disease mechanisms, perform genomic characterisation of vascular disease and its risk factors, particularly Lp(a), and in determining predictors of patient response to therapy.
Jemma leads and collaborates on numerous trial-based, epidemiological, and genetic epidemiological projects involving CTSU's vascular mega-trials (e.g. HPS, SEARCH, THRIVE, REVEAL), large-scale studies and biobanks (e.g. PROCARDIS, UK Biobank), and international consortia (e.g.CARDIoGRAMplusC4D), and working with colleagues from across academia and other industries.
She has Steering Committee, DMC and invited expert roles in numerous large-scale studies and clinical trials, as well as for national agencies and funders, ranging from the Lp(a) Scientific Advisory Board, to MHRA, British Heart Foundation Project Grants Committee Member, to Chairing the American Heart Association Fellowship Committee (Human Studies 22-23).
Hopewell Group (Cardiovascular Precision Medicine)
- Research Staff & Affiliates
Dr Parag Gajendragadkar, Senior Clinical Fellow
Dr Imen Hammami, Senior Medical Statistician
Federico Murgia, Bioinformatician
Dr Alison Offer, Senior Statistical Programmer
Dr Elsa Valdes-Marquez, Senior Medical Statistician
Adam Von Ende, Medical Statistician & Epidemiologist
Dr Ange Tchuisseu, DPhil student
Dr Christian Fielder Camm, Hopewell group affiliate
Administration
Luiza Scurtu, Personal Assistant
- Past Staff and Students
Dr Stephen Brennan, MSc Student
Alexander Tinworth, MSc Student
Dr Christian Fielder Camm, DPhil student and British Heart Foundation Clinical Research Training Fellow
Dr Katerina Lind, DPhil student
Dr Alexander Stiby, Senior Genetic Epidemiologist
Dr Maddalena Ardissino, MSc Student
Cori Campbell, Oxford British Heart Foundation Centre for Research Excellence Student
Lorna Cowan, Oxford British Heart Foundation Centre for Research Excellence Student
Tanya Domun, UNIQ+/Oxford British Heart Foundation Centre for Research Excellence Student
Dr Parag Gajendragadkar, DPhil Student & British Heart Foundation Clinical Research Training Fellow
Dr Issaac Ghinai, MSc Student
Mengyu Gu, Statistical Training Fellow
Dr Maysson Ibrahim, Senior Bioinformatician
Kingwai Lau, Bioinformatician
Dr Lerato Magosi, DPhil Student
Dr Evangelos Oikonomou, DPhil Student
Jonathan Tan, RSCI Student
Larissa Ange Tchuisseu-Kwangoua, Genetic Epidemiology Clinical Intern
Hanning Zhu, Medical Statistician
Recent publications
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Proteomic profiling identifies novel independent relationships between inflammatory proteins and myocardial infarction.
Journal article
Valdes-Marquez E. et al, (2023), Eur J Prev Cardiol
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Apolipoprotein Proteomics for Residual Lipid-Related Risk in Coronary Heart Disease.
Journal article
Clarke R. et al, (2023), Circulation research
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Discovery and systematic characterization of risk variants and genes for coronary artery disease in over a million participants.
Journal article
Aragam KG. et al, (2022), Nature genetics, 54, 1803 - 1815
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Publisher Correction: Stroke genetics informs drug discovery and risk prediction across ancestries.
Journal article
Mishra A. et al, (2022), Nature
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Stroke genetics informs drug discovery and risk prediction across ancestries.
Journal article
Mishra A. et al, (2022), Nature, 611, 115 - 123