Obesity and type 2 diabetes (T2D) are common and complex metabolic diseases, which are caused by an interchange between environmental and genetic factors. Recently, a number of large-scale genome-wide association studies (GWAS) have improved our knowledge of the genetic architecture and biological mechanisms of these diseases. Currently, more than ~250 genetic loci have been found for monogenic, syndromic, or common forms of T2D and/or obesity-related traits. In this review, we discuss the implications of these GWAS for obesity and T2D, and investigate the overlap of loci for obesity-related traits and T2D, highlighting potential mechanisms that affect T2D susceptibility.

Original publication

DOI

10.1007/s11892-015-0648-8

Type

Journal article

Journal

Current diabetes reports

Publication Date

10/2015

Volume

15

Addresses

Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, OX3 7BN, Oxford, UK. tugce.karaderi@well.ox.ac.uk.

Keywords

Animals, Humans, Diabetes Mellitus, Type 2, Obesity, Genetic Predisposition to Disease, Adiponectin, Genome-Wide Association Study, Genetic Loci