Obesity and type 2 diabetes (T2D) are common and complex metabolic diseases, which are caused by an interchange between environmental and genetic factors. Recently, a number of large-scale genome-wide association studies (GWAS) have improved our knowledge of the genetic architecture and biological mechanisms of these diseases. Currently, more than ~250 genetic loci have been found for monogenic, syndromic, or common forms of T2D and/or obesity-related traits. In this review, we discuss the implications of these GWAS for obesity and T2D, and investigate the overlap of loci for obesity-related traits and T2D, highlighting potential mechanisms that affect T2D susceptibility.

Original publication

DOI

10.1007/s11892-015-0648-8

Type

Journal article

Journal

Curr Diab Rep

Publication Date

10/2015

Volume

15

Keywords

Adiponectin, Beta-cell function, Body mass index, Fat distribution, Fat percent, Genome-wide association study, Insulin resistance, Leptin, Non-alcoholic fatty liver disease, Obesity, Pericardial fat, Sexual dimorphism, Subcutaneous fat, Type 2 diabetes, Visceral fat, Waist-to-hip ratio, Adiponectin, Animals, Diabetes Mellitus, Type 2, Genetic Loci, Genetic Predisposition to Disease, Genome-Wide Association Study, Humans, Obesity