Professor Katrina Lythgoe
|Tel||+44 (0)1865 271109|
Research Group Leader
- Sir Henry Dale Fellow
In our group, we are interested in the evolutionary epidemiology of viral infections, including HIV, Hepatitis C and Hepatitis B. We use a combination of approaches, including population genetics, deterministic and stochastic modelling, and the evolutionary analysis of viral sequence data. More specifically, we are interested in evolutionary and ecological processes operating at different ecological scales (e.g. within- and between-host), to assess the impact this integration of scales has on our understanding of the evolution and epidemiology of infectious disease. Our ultimate aim is to produce better predictive models of the consequences of interventions, including the spread of transmitted drug resistance, changing levels of viral virulence, and adaptation of viruses to host immunological backgrounds.
A transmission-virulence evolutionary trade-off explains attenuation of HIV-1 in Uganda
Blanquart F. et al, (2016), eLife
Large Variations in HIV-1 Viral Load Explained by Shifting-Mosaic Metapopulation Dynamics
Lythgoe KA. et al, (2016), PLOS BIOLOGY, 14
Virulence and Pathogenesis of HIV-1 Infection: An Evolutionary Perspective
Fraser C. et al, (2014), SCIENCE, 343, 1328 - +
Preexposure prophylaxis will have a limited impact on HIV-1 drug resistance in sub-Saharan Africa: a comparison of mathematical models.
van de Vijver DAMC. et al, (2013), AIDS, 27, 2943 - 2951
IS HIV SHORT-SIGHTED? INSIGHTS FROM A MULTISTRAIN NESTED MODEL
Lythgoe KA. et al, (2013), EVOLUTION, 67, 2769 - 2782