Dr David Eyre
Robertson Fellow and Infectious Diseases Clinician
My research interests include the use of whole-genome sequencing as a tool for understanding the epidemiology and transmission of bacterial and fungal pathogens. My previous work has described the transmission of the major healthcare-associated pathogen Clostridium difficile and has also included large-scale sequencing projects tracking the spread of gonorrhoea and the emerging multi-drug resistant fungus Candida auris. I am currently working on developing mathematical models for pathogen transmission that allow risk factors for transmission to be identified, as a means to suggest potential interventions to prevent infections spreading.
I am also interested in using sequencing technologies as a novel tool for culture-independent microbiology diagnostics. These technologies offer the prospect of same-day diagnosis of infection, rather than having to wait several days for bacteria to grow in the lab. I have developed methods using sequencing data to detect the presence of infection, e.g. from orthopedic devices removed from patients, as well as predict antibiotic resistance, e.g. in Enterobacteriaceae and Neisseria gonorrhoeae.
Additionally I work on using routinely collected healthcare data to investigate the epidemiology of infectious diseases and to investigate individual patient responses to infection and treatment.
I work closely with the Modernising Medical Microbiology consortium on several of these projects.
A Candida auris Outbreak and Its Control in an Intensive Care Setting.
Eyre DW. et al, (2018), The New England journal of medicine, 379, 1322 - 1331
Real-time analysis of nanopore-based metagenomic sequencing from infected orthopaedic devices.
Sanderson ND. et al, (2018), BMC genomics, 19
Two Distinct Patterns of Clostridium difficile Diversity Across Europe Indicating Contrasting Routes of Spread.
Eyre DW. et al, (2018), Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 67, 1035 - 1044
Gonorrhoea treatment failure caused by a Neisseria gonorrhoeae strain with combined ceftriaxone and high-level azithromycin resistance, England, February 2018.
Eyre DW. et al, (2018), Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin, 23
Clostridium difficile: Investigating Transmission Patterns between Infected and Colonized Patients using whole Genome Sequencing.
Kong LY. et al, (2018), Clinical infectious diseases : an official publication of the Infectious Diseases Society of America