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Progress towards malaria elimination in Africa has stalled, and insecticide resistance is a major challenge for malaria control programmes because of a heavy reliance on insecticide-treated bednets and indoor residual spraying as core interventions. However, new nets and new insecticides have recently become available for public health use, and insecticide resistance management guided by surveillance data is becoming a practical prospect. I will give an overview of work within MalariaGEN to scale up whole genome sequencing of African malaria vectors, and discuss opportunities and challenges in the use of genomic data for surveillance of insecticide resistance.