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Knowledge of epidemiological mechanisms and parameters underlying scrapie transmission in sheep flocks remains very limited at present. Here we introduce a method for fitting stochastic transmission models to outbreak data to estimate bounds on key transmission parameters. We apply this method to data describing an outbreak of scrapie in a closed flock of Romanov sheep. The main findings are that the relative infectiousness of infected animals in this outbreak becomes appreciable early into disease incubation and that the mean incubation period is less than 1.5 years. We also find that the data are consistent with a broad range of values for the basic reproduction number R0 and describe how the boundaries of this range depend on assumptions about the mean incubation period and the contribution to transmission of a long-lived environmental reservoir of infectivity.

Original publication

DOI

10.1017/s0950268803001055

Type

Journal article

Journal

Epidemiology and infection

Publication Date

10/2003

Volume

131

Pages

1015 - 1022

Addresses

Department of Infectious Disease Epidemiology, Faculty of Medicine, Imperial College London, St Marys' Campus, Norfolk Place, London W2 1PG.

Keywords

Animals, Sheep, Scrapie, Models, Statistical, Disease Outbreaks, Genotype, Computer Simulation, Disease Transmission, Infectious, United Kingdom