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AIMS: We investigated whether the insertion/deletion (I/D) polymorphism of the ACE gene modified the adherence to ACE inhibitors as measured by the discontinuation of an ACE inhibitor, or addition of another antihypertensive drug. METHODS: This was a cohort study among 239 subjects who started ACE inhibitor therapy. A Cox proportional hazard model was used to calculate relative risk (RR). RESULTS: During follow-up there was no significant difference between subjects with the DD, ID or II genotype (DD vs II; RR = 1.17, 95%CI: 0.78, 1.77 and ID vs II; RR = 1.06, 95%CI: 0.73, 1.55) in adherence. CONCLUSIONS: The I/D polymorphism of the ACE gene does not influence the adherence to ACE inhibitors.

Original publication




Journal article


British journal of clinical pharmacology

Publication Date





483 - 485


Department of Epidemiology & Biostatistics, Erasmus MC, Rotterdam, The Netherlands.


Humans, Hypertension, DNA Transposable Elements, Antihypertensive Agents, Angiotensin-Converting Enzyme Inhibitors, Analysis of Variance, Risk Assessment, Cohort Studies, Prospective Studies, Polymerase Chain Reaction, Patient Compliance, Gene Deletion, Genotype, Polymorphism, Genetic, Aged, Middle Aged