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We recently reported linkage to chromosome 1p36 (the PARK7-locus) in a family with early-onset parkinsonism. Linkage to this locus has since been confirmed in an independent data set. We describe clinical and neuroimaging features of the 4 patients in the original PARK7-linked kindred. Age at onset of parkinsonism varied from 27 to 40 years. Clinical progression was slow, and response to dopaminergic therapy good. The clinical spectrum ranged from mild hypokinesia and rigidity, to severe parkinsonism with levodopa-induced dyskinesias and motor fluctuation. Three of four patients with PARK7-linked parkinsonism exhibited psychiatric disturbances. Structural neuroimaging was unremarkable, but functional imaging of the brain, carried out in 3 patients, showed significant evidence for a presynaptic dopamine deficit, and assessment of cerebral glucose metabolism, as carried out in 1 patient, showed possible cerebellar involvement.

Original publication




Journal article


Movement disorders : official journal of the Movement Disorder Society

Publication Date





751 - 757


Genetic-Epidemiologic Unit, Departments of Epidemiology and Biostatistics and Clinical Genetics, Erasmus Medical Centre Rotterdam, The Netherlands.


Substantia Nigra, Corpus Striatum, Nerve Net, Chromosomes, Human, Pair 1, Humans, Parkinsonian Disorders, Disease Progression, Intracellular Signaling Peptides and Proteins, Oncogene Proteins, Diagnostic Imaging, Neurologic Examination, Chromosome Mapping, Heterozygote Detection, Pedigree, Consanguinity, Phenotype, Adult, Middle Aged, Netherlands, Female, Male