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OBJECTIVE:To examine the association between the APOE genotype and cardiovascular disease in Alzheimer's disease (AD) patients. DESIGN:Case register study of 100 consecutive referrals to a Memory Clinic where type of dementia and cardiovascular comorbidity were diagnosed and APOE genotype was determined. SETTING:The Memory Clinic, University Hospital Rotterdam Dijkzigt. PARTICIPANTS:One hundred Memory Clinic patients, 59 to 91 years of age, who attended the Memory Clinic in the period between January 1994 and March 1996. MEASUREMENTS:Relative risk of cardiovascular morbidity in probable AD, based on clinical and ECG findings. RESULTS:The diagnosis of probable AD was more frequent in APOE*4 allele-carrying AD patients. When comparing homozygotes for APOE*4 with homozygotes for APOE*3, a nine-fold increase in prevalence of cardiac ischemia on ECG was found in the former. When grouping parameters of left ventricular dysfunction, the prevalence was 7.2 (95% confidence interval 1.2-42.6) times greater in probable Alzheimer patients with APOE4/4. CONCLUSIONS:In patients with probable AD, APOE*4 is associated with cardiac disease indicative of left ventricular dysfunction.

Original publication

DOI

10.1111/j.1532-5415.1998.tb02749.x

Type

Journal article

Journal

Journal of the American Geriatrics Society

Publication Date

08/1998

Volume

46

Pages

962 - 967

Addresses

Department of Internal Medicine I and Geriatric Medicine, Erasmus University Medical School, Rotterdam, The Netherlands.

Keywords

Humans, Alzheimer Disease, Cardiovascular Diseases, Ventricular Dysfunction, Left, Apolipoproteins E, Odds Ratio, Risk Factors, Genotype, Alleles, Aged, Aged, 80 and over, Middle Aged, Female, Male