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While angiotensinogen (AGT) seems to have anti proliferative properties, angiotensin II (ATII) is a potent growth factor and it mediates its actions through the angiotensin type 1 receptor (AGTR1). In the AGT gene, the M235T polymorphism has been associated with the variation in angiotensinogen levels and in the AGTR1 gene; the C573T variant is associated with different pathologies. We aimed to evaluate the relationship of these two variants and the risk of breast cancer. These polymorphisms were genotyped in 3787 women participating the Rotterdam Study. We performed a logistic regression and a disease free survival analysis by genotype. The logistic regression yielded an odds ratio of 1.4 (95% CI: 1.1-1.9) for the MM genotype carriers versus the T allele carriers. The breast cancer free survival by AGT genotype was significantly reduced in MM genotype carriers compared to non-carriers (hazard ratio (HR) = 1.5; 95% CI: 1.1-2.2). We did not find any association of the AGTR1 polymorphism and breast cancer risk or disease free survival. Our results suggest that AGT plays a role in breast cancer risk in postmenopausal women, whereas the role of AGTR1 needs further studying.

Original publication

DOI

10.1007/s10549-006-9290-0

Type

Journal article

Journal

Breast cancer research and treatment

Publication Date

03/2007

Volume

101

Pages

299 - 304

Addresses

Department of Epidemiology & Biostatistics, Erasmus University Medical Center, Postbus 1738, 3000 DR, Rotterdam, The Netherlands.

Keywords

Humans, Breast Neoplasms, Genetic Predisposition to Disease, Angiotensinogen, Receptor, Angiotensin, Type 1, DNA, Body Mass Index, Disease-Free Survival, Prevalence, Risk Factors, Case-Control Studies, Follow-Up Studies, DNA Mutational Analysis, Genotype, Polymorphism, Single Nucleotide, Aged, Aged, 80 and over, Middle Aged, Netherlands, Female, Genetic Testing