Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

The DJ-1 gene is associated with autosomal recessive early-onset Parkinsonism, most likely through its role in defense against oxidative stress. Oxidative stress is not only involved in Parkinson's disease, but also in other neurodegenerative disorders, such as dementia. We assessed the presence of a 14 kb DJ-1 deletion in 191 patients with dementia, ascertained from the genetically isolated population where the first kindred with DJ-1 related Parkinsonism was originally identified. The control group consisted of 129 non-demented subjects. We found the deletion in two patients and one control. There was no evidence for an increased risk of dementia in carriers. All subjects were heterozygous for the deletion and related to a common ancestor within eight generations. Our results suggest it is unlikely that haploinsufficiency in the DJ-1 gene imparts an increased risk for dementia.

Original publication

DOI

10.1016/j.neulet.2004.09.040

Type

Journal article

Journal

Neuroscience letters

Publication Date

12/2004

Volume

372

Pages

196 - 199

Addresses

Genetic-Epidemiology Unit, Department of Epidemiology and Biostatistics, Erasmus MC, P.O. Box 1738, 3000 DR Rotterdam, The Netherlands. a.ariasvasquez@erasmusmc.nl

Keywords

Humans, Dementia, Alzheimer Disease, Intracellular Signaling Peptides and Proteins, Oncogene Proteins, Data Collection, Risk Assessment, Case-Control Studies, Behavior, Gene Deletion, Gene Frequency, Heterozygote, Aged, Aged, 80 and over, Population, Netherlands, Female, Male, Protein Deglycase DJ-1