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Osteoporosis and osteoarthritis are age-related disorders of the skeleton with genetic components. Low bone density is a risk factor for osteoporotic fracture while osteoarthritis is associated with increased bone density. The 1,25-dihydroxyvitamin D3 receptor (VDR) gene locus was previously found to be associated with bone density. We therefore studied the relationship between radiographic osteoarthritis at the knee and VDR genotype in a population-based sample (n = 846), using molecular haplotyping of anonymous intragenic DNA polymorphisms. Radiographic osteoarthritis was defined using the Kellgren score, which is based on the assessment of osteophytes and joint space narrowing (JSN). We show that one VDR haplotype allele is significantly overrepresented in individuals with knee osteoarthritis and associated with a 2.27-fold increased relative risk (95% confidence interval 1.46, 3.52). Adjustment for bone density at the femoral neck did not change these results, indicating that the association is not mediated by bone density. The association appeared to be largely explained by the presence of osteophytes rather than JSN. Our results indicate a role of the VDR gene in the pathogenesis of osteophytes while linkage disequilibrium with another nearby gene, i.e., the collagen type IIa1 gene encoding the most abundant protein in cartilage, might contribute to the association.

Original publication

DOI

10.1172/jci119530

Type

Journal article

Journal

The Journal of clinical investigation

Publication Date

07/1997

Volume

100

Pages

259 - 263

Addresses

Department of Internal Medicine III, Erasmus University Medical School, 3000 DR Rotterdam, The Netherlands. uitterlinden@inw3.azr.nl

Keywords

Knee Joint, Humans, Osteoporosis, Osteoarthritis, Receptors, Calcitriol, Risk Factors, Prospective Studies, Polymerase Chain Reaction, Bone Density, Genotype, Polymorphism, Genetic, Polymorphism, Restriction Fragment Length, Alleles, Aged, Middle Aged, Female, Male, Genetic Linkage