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The -491 polymorphism in the promoter region of the apolipoprotein E gene (APOE) has been suggested to be associated with increased risk for Alzheimer's disease (AD) independent of APOE status. We studied the association between the -491 polymorphism and risk for early-onset Alzheimer's disease in 99 Dutch and 78 Spanish patients. In patients with early-onset AD, we found no consistent relationship with a single allele of the -491 polymorphism. Linkage disequilibrium between the polymorphism and the APOE gene was found which most likely might explain the inconsistent findings.

Original publication




Journal article


Neuroscience letters

Publication Date





65 - 68


Department of Epidemiology and Biostatistics, Erasmus University Medical School, Rotterdam, The Netherlands.


Chromosomes, Human, Pair 19, Humans, Alzheimer Disease, Apolipoproteins E, Age of Onset, Regulatory Sequences, Nucleic Acid, Gene Frequency, Genotype, Linkage Disequilibrium, Point Mutation, Polymorphism, Genetic, Alleles, Middle Aged, Genetic Testing, Genetic Linkage