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A power calculation is described in which the power of selective genotyping in genetic association studies of quantitative traits is evaluated. The method of selective genotyping implies the selection of the extremely high and low scoring individuals from the continuous distribution of a quantitative trait. The selected individuals are genotyped and association is tested. In the power calculation the following parameters are varied: total sample size of the phenotyped group (1000, 1500, 2000); selection of extremely high and low scoring individuals (2.5%, 5%, 10%); allele frequency of the risk increasing allele (0.10 to 0.90); mode of inheritance and proportion of variance explained by the quantitative trait locus (QTL) (omega 2 = 0.01, 0.05, 0.10). We conclude that the method of selective genotyping is a powerful method to detect association for a quantitative trait.

Original publication

DOI

10.1023/a:1001907321955

Type

Journal article

Journal

Behavior genetics

Publication Date

03/2000

Volume

30

Pages

141 - 146

Addresses

Flanders Interuniversity Institute for Biotechnology (VIB), University of Antwerp (UIA), Department of Biochemistry, Belgium.

Keywords

Humans, Chromosome Mapping, Genotype, Quantitative Trait, Heritable, Phenotype, Models, Genetic, Selection, Genetic