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BACKGROUND: We conducted a meta-analysis to re-evaluate the role of the dopamine D4 receptor gene 48-base-pair- repeat (DRD4) polymorphism in mood disorders. METHODS: DRD4 allele frequencies were compared between 917 patients with unipolar (UP) or bipolar affective disorder (BP) and 1164 control subjects from 12 samples, using the Cochrane Review Manager. RESULTS: An association was found between all mood disorder groups and DRD4.2. After correcting for multiple testing, the association between DRD4.2 and BP dropped to insignificance; however, the evidence of an association between the DRD4.2 allele and UP (p < .001) and the combined group (p < .001) remained. There was no evidence for heterogeneity or publication bias. CONCLUSIONS: These findings suggest that the DRD4.2 allele is a risk allele for depression symptomatology. Meta-analysis may be a valuable objective tool for a quantitative summary of evidence for association studies in psychiatric genetics.

Original publication

DOI

10.1016/j.biopsych.2005.01.030

Type

Journal article

Journal

Biological psychiatry

Publication Date

05/2005

Volume

57

Pages

999 - 1003

Addresses

Genetic Epidemiology Unit, Department of Epidemiology and Biostatistics, Erasmus Medical Center, Rotterdam, The Netherlands.

Keywords

Humans, Receptors, Dopamine D2, Confidence Intervals, Odds Ratio, Case-Control Studies, Mood Disorders, Minisatellite Repeats, Gene Frequency, Polymorphism, Genetic, Alleles, Receptors, Dopamine D4