Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

The STOX1 gene, identified as a candidate gene for pre-eclampsia in Dutch women, is placentally expressed and subject to imprinting with preferential transmission of the maternal allele. In our study, STOX1-Y153H frequencies were similar in 157 women with pre-eclampsia (65%) and in 157 controls (64%) from the general Dutch population. In an isolated Dutch population, a distortion could not be demonstrated in the transmission of STOX1-Y153H variation from heterozygous mothers to offspring in 50 and 56 families with pregnancies complicated by pre-eclampsia or intrauterine growth restriction, respectively. Our findings do not confirm previous suggestions that STOX1 plays a major role in Dutch women with pre-eclampsia.

Original publication

DOI

10.1111/j.1471-0528.2007.01414.x

Type

Journal article

Journal

BJOG : an international journal of obstetrics and gynaecology

Publication Date

09/2007

Volume

114

Pages

1163 - 1167

Addresses

Division of Obstetrics and Prenatal Medicine, Department of Obstetrics and Gynaecology, Erasmus MC, University Medical Centre Rotterdam, Rotterdam, The Netherlands.

Keywords

Humans, Fetal Growth Retardation, Pre-Eclampsia, Carrier Proteins, Case-Control Studies, Pedigree, Pregnancy, Gene Frequency, Heterozygote, Homozygote, Female