Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

To follow-up loci discovered by the International Genomics of Alzheimer's Disease Project, we attempted independent replication of 19 single nucleotide polymorphisms (SNPs) in a large Spanish sample (Fundació ACE data set; 1808 patients and 2564 controls). Our results corroborate association with four SNPs located in the genes INPP5D, MEF2C, ZCWPW1 and FERMT2, respectively. Of these, ZCWPW1 was the only SNP to withstand correction for multiple testing (P=0.000655). Furthermore, we identify TRIP4 (rs74615166) as a novel genome-wide significant locus for Alzheimer's disease risk (odds ratio=1.31; confidence interval 95% (1.19-1.44); P=9.74 × 10(-)(9)).

Original publication

DOI

10.1038/tp.2014.2

Type

Journal article

Journal

Translational psychiatry

Publication Date

04/02/2014

Volume

4

Keywords

IGAP, Humans, Alzheimer Disease, Genetic Predisposition to Disease, Transcription Factors, Follow-Up Studies, Polymorphism, Single Nucleotide, Spain, Genome-Wide Association Study, Genetic Loci