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This study aims to identify the lifestyle determinants of insulin-like growth factor-I (IGF-I) and its main binding proteins (IGFBPs), C-peptide, and sex hormone-binding globulin (SHBG) to help elucidate the mechanism through which lifestyle factors may affect cancer risk.This study is based on a sample of 292 British women, aged 20-70 years, whose lifestyle characteristics were assessed using a self-administered questionnaire and whose serum hormone concentrations were measured using immunoassays.Age was a strong determinant of both IGF-I and IGFBP levels; women aged 65-70 years had significantly lower IGF-I and IGFBP-3 concentrations and significantly higher IGFBP-1 and IGFBP-2 concentrations than women aged 20-24 years. Body mass index (BMI) was not strongly associated with IGF-I, although women with a BMI of 26-27.9 kg/m2 had a higher IGF-I concentration compared with both lean (BMI <20 kg/m2) and obese (BMI 30+ kg/m2) women. However, obese women had a significantly higher C-peptide and IGFBP-3 concentration and a significantly lower IGFBP-1, IGFBP-2, and SHBG concentration compared with lean women. Increasing vigorous exercise was associated with a significantly lower C-peptide concentration and increasing leisure-time activity was associated with a significantly higher IGFBP-1 concentration. Other lifestyle factors such as job activity, smoking, and reproductive factors were not associated with any hormone.Our data show that age is a major determinant of both IGF-I and its main binding proteins in women. BMI has strong effects on IGFBPs, C-peptide, and SHBG, but its effects on IGF-I remain unclear. The possible effect of physical activity on IGFBP-1 requires further investigation.

Original publication

DOI

10.1023/a:1022518321634

Type

Journal article

Journal

Cancer causes & control : CCC

Publication Date

02/2003

Volume

14

Pages

65 - 74

Addresses

Cancer Research UK Epidemiology Unit, University of Oxford, Radcliffe Infirmary, Oxford, OX2 6HE, UK. naomi.allen@cancer.org.uk

Keywords

Humans, Neoplasms, C-Peptide, Insulin-Like Growth Factor I, Sex Hormone-Binding Globulin, Insulin-Like Growth Factor Binding Protein 1, Body Mass Index, Risk, Motor Activity, Life Style, Age Factors, Adult, Middle Aged, Female, United Kingdom