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We conducted meta-analyses of genome-wide association studies for atrial fibrillation (AF) in participants from five community-based cohorts. Meta-analyses of 896 prevalent (15,768 referents) and 2,517 incident (21,337 referents) AF cases identified a new locus for AF (ZFHX3, rs2106261, risk ratio RR = 1.19; P = 2.3 x 10(-7)). We replicated this association in an independent cohort from the German AF Network (odds ratio = 1.44; P = 1.6 x 10(-11); combined RR = 1.25; combined P = 1.8 x 10(-15)).

Original publication




Journal article


Nature genetics

Publication Date





879 - 881


National Heart, Lung, and Blood Institute's Framingham Heart Study, Framingham, Massachusetts, USA.


Chromosomes, Human, Pair 16, Humans, Atrial Fibrillation, Genetic Predisposition to Disease, Homeodomain Proteins, Reproducibility of Results, Mutation, Polymorphism, Single Nucleotide, European Continental Ancestry Group, Meta-Analysis as Topic, Genome-Wide Association Study