Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

Genome-wide association studies have identified single-nucleotide polymorphisms (SNPs) for intracranial aneurysms in clinical samples. In addition, SNPs have been discovered for blood pressure, one of the strongest risk factors for intracranial aneurysms. We studied the role of these genetic variants on occurrence and size of unruptured intracranial aneurysms, discovered incidentally in a general community-dwelling population.In 4890 asymptomatic participants from the Rotterdam Study, 120 intracranial aneurysms were identified on brain imaging and segmented for maximum diameter and volume. Genetic risk scores (GRS) were calculated for intracranial aneurysms (10 SNPs), systolic blood pressure (33 SNPs), and diastolic blood pressure (41 SNPs).The GRS for intracranial aneurysms was not statistically significantly associated with presence of aneurysms in this population (OR, 1.16; 95% CI, 0.96-1.40; P=0.119), but showed a significant association with both maximum diameter (difference in log-transformed mm per SD increase of GRS, 0.10; 95% CI, 0.02-0.19; P=0.018) and volume (difference in log-transformed µL per SD increase of GRS, 0.21; 95% CI, 0.01-0.41; P=0.040) of aneurysms. GRSs for blood pressures were associated with neither presence nor size of aneurysms.Genetic variants previously identified for intracranial aneurysms in clinical studies relate to the size rather than the presence of incidentally discovered, unruptured intracranial aneurysms in the general population.

Original publication

DOI

10.1161/strokeaha.115.010414

Type

Journal article

Journal

Stroke

Publication Date

10/2015

Volume

46

Pages

2961 - 2964

Addresses

From the Departments of Epidemiology (A.P., H.H.H.A., L.G.M.C., A.H., C.M.v.D., A.G.U., M.W.V., M.A.I.), Neurology (M.A.I.), Radiology (H.H.H.A., L.G.M.C., G.K., A.v.d.L., M.W.V., M.A.I.), and Internal Medicine (A.G.U.), Erasmus University Medical Center, Rotterdam, The Netherlands.

Keywords

Humans, Intracranial Aneurysm, Genetic Predisposition to Disease, Cohort Studies, Prospective Studies, Blood Pressure, Polymorphism, Single Nucleotide, Aged, Middle Aged, Netherlands, Female, Male, Genome-Wide Association Study