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The enduring changes in long-term memory probably depend on regulation of gene expression in the hippocampus. To seek genes regulated by learning, we used microarray technology to compare hippocampal gene expression in mice undergoing training in the Morris water maze and control mice forced to swim for the same period in the absence of a hidden platform. ANOVA was employed to prioritize genes for further study, and three genes were confirmed by real-time PCR as being regulated during learning. One of the genes was the alpha subunit of the platelet-derived growth factor receptor (Pdgfra); another showed homology to DnaJ and cAMP response element-binding protein 2 (CREB2); and a third was novel. These genes may provide useful insights into the molecular mechanisms of hippocampal learning.

Original publication

DOI

10.1002/jnr.10541

Type

Journal article

Journal

Journal of neuroscience research

Publication Date

03/2003

Volume

71

Pages

763 - 768

Addresses

Department of Molecular and Medical Pharmacology, Crump Institute for Molecular Imaging, UCLA School of Medicine, Los Angeles, California, USA.

Keywords

Hippocampus, Animals, Mice, Receptor, Platelet-Derived Growth Factor alpha, Heat-Shock Proteins, Transcription Factors, Oligonucleotide Array Sequence Analysis, Gene Expression Profiling, Reverse Transcriptase Polymerase Chain Reaction, Maze Learning, Memory, Gene Expression Regulation, Sequence Homology, Male, HSP40 Heat-Shock Proteins, Activating Transcription Factor 4