Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system. MS lesions show a typical distribution pattern and primarily affect the white matter (WM) in the periventricular zone and in the centrum semiovale.To track lesion development during disease progression, we compared the spatiotemporal distribution patterns of lesions in relapsing-remitting MS (RRMS) and secondary progressive MS (SPMS).We used T1 and T2 weighted MR images of 209 RRMS and 62 SPMS patients acquired on two different 1.5 Tesla MR scanners in two clinical centers followed up for 25 (± 1.7) months. Both cross-sectional and longitudinal differences in lesion distribution between RRMS and SPMS patients were analyzed with lesion probability maps (LPMs) and permutation-based inference.MS lesions clustered around the lateral ventricles and in the centrum semiovale. Cross-sectionally, compared to RRMS patients, the SPMS patients showed a significantly higher regional probability of T1 hypointense lesions (p ≤ 0.03) in the callosal body, the corticospinal tract, and other tracts adjacent to the lateral ventricles, but not of T2 lesions (peak probabilities were RRMS: T1 9%, T2 18%; SPMS: T1 21%, T2 27%). No longitudinal changes of regional T1 and T2 lesion volumes between baseline and follow-up scan were found.The results suggest a particular vulnerability to neurodegeneration during disease progression in a number of WM tracts.

Original publication

DOI

10.1177/1352458512442756

Type

Journal article

Journal

Multiple sclerosis (Houndmills, Basingstoke, England)

Publication Date

11/2012

Volume

18

Pages

1577 - 1584

Addresses

Medical Image Analysis Center, University Hospital Basel, Basel, Switzerland.

Keywords

Brain, Humans, Multiple Sclerosis, Chronic Progressive, Multiple Sclerosis, Relapsing-Remitting, Disease Progression, Magnetic Resonance Imaging, Disability Evaluation, Analysis of Variance, Chi-Square Distribution, Predictive Value of Tests, Time Factors, Adult, Middle Aged, Europe, Female, Male, Leukoencephalopathies