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Some of the many ways in which mathematical biology and statistics have been used in investigating the acquired immunodeficiency syndrome (AIDS) epidemic are reviewed. Aspects of the spread of the disease via social and sexual networks are discussed. The different kinds of data involved are critically compared. Some studies of the incubation period are briefly reviewed and some comments made on the role of adherence to therapy.

Original publication




Journal article


Statistical methods in medical research

Publication Date





141 - 154


Department of Infectious Disease Epidemiology, Imperial College School of Medicine, St Mary's Campus, Norfolk Place, London W2 1PG, UK.


Humans, HIV Infections, Acquired Immunodeficiency Syndrome, Antiretroviral Therapy, Highly Active, Epidemiologic Methods, Models, Statistical, Patient Compliance, Sexual Behavior, Disease Outbreaks, Biometry, Models, Biological, Time Factors, Databases, Factual, Female, Male, Clinical Trials as Topic