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Migraine is the most common brain disorder, affecting approximately 14% of the adult population, but its molecular mechanisms are poorly understood. We report the results of a meta-analysis across 29 genome-wide association studies, including a total of 23,285 individuals with migraine (cases) and 95,425 population-matched controls. We identified 12 loci associated with migraine susceptibility (P<5×10(-8)). Five loci are new: near AJAP1 at 1p36, near TSPAN2 at 1p13, within FHL5 at 6q16, within C7orf10 at 7p14 and near MMP16 at 8q21. Three of these loci were identified in disease subgroup analyses. Brain tissue expression quantitative trait locus analysis suggests potential functional candidate genes at four loci: APOA1BP, TBC1D7, FUT9, STAT6 and ATP5B.

Original publication

DOI

10.1038/ng.2676

Type

Journal article

Journal

Nature genetics

Publication Date

08/2013

Volume

45

Pages

912 - 917

Addresses

Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge, UK.

Keywords

North American Brain Expression Consortium, UK Brain Expression Consortium, Cerebellum, Frontal Lobe, Humans, Genetic Predisposition to Disease, Computational Biology, Polymorphism, Single Nucleotide, Quantitative Trait Loci, Migraine Disorders, Genome-Wide Association Study, Genetic Loci