Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

We systematically reviewed the current understanding of human population immunity against SARS-CoV in different groups, settings and geography. Our meta-analysis, which included all identified studies except those on wild animal handlers, yielded an overall seroprevalence of 0.10% [95% confidence interval (CI) 0.02-0.18]. Health-care workers and others who had close contact with SARS patients had a slightly higher degree of seroconversion (0.23%, 95% CI 0.02-0.45) compared to healthy blood donors, others from the general community or non-SARS patients recruited from the health-care setting (0.16%, 95% CI 0-0.37). When analysed by the two broad classes of testing procedures, it is clear that serial confirmatory test protocols resulted in a much lower estimate (0.050%, 95% CI 0-0.15) than single test protocols (0.20%, 95% CI 0.06-0.34). Potential epidemiological and laboratory pitfalls are also discussed as they may give rise to false or inconsistent results in measuring the seroprevalence of IgG antibodies to SARS-CoV.

Original publication

DOI

10.1017/s0950268805004826

Type

Journal article

Journal

Epidemiology and infection

Publication Date

04/2006

Volume

134

Pages

211 - 221

Addresses

Department of Community Medicine, University of Hong Kong, Pokfulam, Hong Kong, ChinaTakemi Program, Harvard School of Public Health, Boston, MA, USA. gmleung@hkucc.hk

Keywords

Humans, SARS Virus, Severe Acute Respiratory Syndrome, Immunoglobulin G, Seroepidemiologic Studies, Antibody Formation, Geography, Health Personnel, Blood Donors