Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

Endometrial cancer is the most common gynecological malignancy in the developed world. Although there is evidence of genetic predisposition to the disease, most of the genetic risk remains unexplained. We present the meta-analysis results of four genome-wide association studies (4907 cases and 11 945 controls total) in women of European ancestry. We describe one new locus reaching genome-wide significance (P < 5 × 10 -8) at 6p22.3 (rs1740828; P = 2.29 × 10 -8, OR = 1.20), providing evidence of an additional region of interest for genetic susceptibility to endometrial cancer.

Original publication

DOI

10.1093/hmg/ddw092

Type

Journal article

Journal

Human molecular genetics

Publication Date

06/2016

Volume

25

Pages

2612 - 2620

Addresses

Program in Genetic Epidemiology and Statistical Genetics, Department of Epidemiology, Harvard TH Chan School of Public Health, Boston, MA 02115, USA.

Keywords

Australian National Endometrial Cancer Study Group (ANECS), National Study Of Endometrial Cancer Genetics Group (NSECG), Chromosomes, Human, Pair 6, Humans, Endometrial Neoplasms, Genetic Predisposition to Disease, Genotype, Polymorphism, Single Nucleotide, European Continental Ancestry Group, Female, Genome-Wide Association Study