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Apart from commercial reasons, two motivations have led to the introduction of SSRIs to replace the first and second generation antidepressants already available. One was the search for a more rational treatment, based on specific mechanisms, the other the development of effective treatments with fewer side effects, particularly for older patients, who have a greater sensitivity to cardio-vascular and central nervous system effects. The first has been frustrated up to a point, in that SSRIs and other single mechanism drugs do not appear to be more effective than the earliest relatively non-specific antidepressants. The second has been fulfilled, in that SSRIs generally are better tolerated in older patients and in overdose. However, there is a spectrum of other side effects that are particularly relevant in older age and that need attention when treating depression in this particular patient group.

Original publication

DOI

10.1016/j.maturitas.2013.11.006

Type

Journal article

Journal

Maturitas

Publication Date

02/2014

Volume

77

Pages

118 - 123

Addresses

Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford OX3 7JX, UK.

Keywords

Humans, Serotonin Uptake Inhibitors, Depression, Aged