Spontaneous fluctuations in activity in different parts of the brain can be used to study functional brain networks. We review the use of resting-state functional MRI (rfMRI) for the purpose of mapping the macroscopic functional connectome. After describing MRI acquisition and image-processing methods commonly used to generate data in a form amenable to connectomics network analysis, we discuss different approaches for estimating network structure from that data. Finally, we describe new possibilities resulting from the high-quality rfMRI data being generated by the Human Connectome Project and highlight some upcoming challenges in functional connectomics.

Original publication

DOI

10.1016/j.tics.2013.09.016

Type

Journal article

Journal

Trends in cognitive sciences

Publication Date

12/2013

Volume

17

Pages

666 - 682

Addresses

Oxford Centre for Functional MRI of the Brain (FMRIB), University of Oxford, Oxford, UK. Electronic address: steve@fmrib.ox.ac.uk.

Keywords

Brain, Nerve Net, Neural Pathways, Animals, Humans, Oxygen, Magnetic Resonance Imaging, Rest, Image Processing, Computer-Assisted