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The 1 microgram oxacillin disk diffusion screening test was performed on 1516 recent clinical isolates of Streptococcus pneumoniae obtained in a 1994-1995 U.S. surveillance study and the results compared to penicillin MICs determined using a standardized broth microdilution method. The oxacillin disk screening method failed to distinguish penicillin-resistant strains from those that were intermediately susceptible. Furthermore, a high percentage (11.1%) of penicillin-susceptible strains, for which MICs of penicillin were usually 0.06 or 0.03 microgram/ml, yielded zone diameters of < or = 19 mm with the oxacillin screen test and thus would have been falsely categorized as being resistant to penicillin.

Original publication

DOI

10.1007/bf01695637

Type

Journal article

Journal

European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology

Publication Date

04/1997

Volume

16

Pages

311 - 314

Addresses

Clinical Microbiology Laboratories, University of Massachusetts Medical Center, Worcester 01655, USA.

Keywords

Streptococcus pneumoniae, Penicillins, Oxacillin, Microbial Sensitivity Tests, Sensitivity and Specificity, Penicillin Resistance