Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

OBJECTIVE: To assess the performance of clinical microbiology laboratories in the United States when conducting in vitro susceptibility tests with Streptococcus pneumoniae. METHODS: The results of a nationwide College of American Pathologists Proficiency Survey test sample, in which susceptibility testing of an isolate of S. pneumoniae was performed, were assessed with respect to precision and accuracy. RESULTS: Wide variability was noted among participating laboratories with both minimum inhibitory concentration procedures and disk diffusion susceptibility tests when both methods were applied to S. pneumoniae. Despite this high degree of variation, categorical interpretive errors were uncommon. Numerous laboratories reported results for antimicrobial agents that are not recommended by the National Committee for Clinical Laboratory Standards for tests with S. pneumoniae. CONCLUSIONS: Current susceptibility testing practices with S. pneumoniae in the United States indicate limited precision and a tendency for laboratories to test and report results obtained with antimicrobial agents of questionable therapeutic value against this organism. Continued efforts to standardize susceptibility testing of S. pneumoniae in the United States are warranted. In addition, modifications of existing interpretive criteria may be necessary.

Original publication

DOI

10.1043/0003-9985(1999)123<0285:aolpws>2.0.co;2

Type

Journal article

Journal

Archives of pathology & laboratory medicine

Publication Date

04/1999

Volume

123

Pages

285 - 289

Addresses

Department of Pathology, University of Iowa College of Medicine, Iowa City 52242, USA.

Keywords

Humans, Streptococcus pneumoniae, Streptococcal Infections, Anti-Bacterial Agents, Microbial Sensitivity Tests, Reproducibility of Results, Drug Resistance, Microbial, Quality Assurance, Health Care