GREVE has been developed to assist with the identification of recurrent genomic aberrations across cancer samples. The exact characterization of such aberrations remains a challenge despite the availability of increasing amount of data, from SNParray to next-generation sequencing. Furthermore, genomic aberrations in cancer are especially difficult to handle because they are, by nature, unique to the patients. However, their recurrence in specific regions of the genome has been shown to reflect their relevance in the development of tumors. GREVE makes use of previously characterized events to identify such regions and focus any further analysis.GREVE is available through a web interface and open-source application (http://www.well.ox.ac.uk/GREVE).

Original publication

DOI

10.1093/bioinformatics/bts547

Type

Journal article

Journal

Bioinformatics (Oxford, England)

Publication Date

11/2012

Volume

28

Pages

2981 - 2982

Addresses

Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, OX3 7BN and Department of Statistics, University of Oxford, 1 South Parks Road, OX1 3TG, Oxford, UK.

Keywords

Humans, Neoplasms, Chromosome Aberrations, Genome, Human, Software, Chromosome Breakpoints