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Obesity is a serious international health problem that increases the risk of several common diseases. The genetic factors predisposing to obesity are poorly understood. A genome-wide search for type 2 diabetes-susceptibility genes identified a common variant in the FTO (fat mass and obesity associated) gene that predisposes to diabetes through an effect on body mass index (BMI). An additive association of the variant with BMI was replicated in 13 cohorts with 38,759 participants. The 16% of adults who are homozygous for the risk allele weighed about 3 kilograms more and had 1.67-fold increased odds of obesity when compared with those not inheriting a risk allele. This association was observed from age 7 years upward and reflects a specific increase in fat mass.

Original publication

DOI

10.1126/science.1141634

Type

Journal article

Journal

Science (New York, N.Y.)

Publication Date

05/2007

Volume

316

Pages

889 - 894

Addresses

Genetics of Complex Traits, Institute of Biomedical and Clinical Science, Peninsula Medical School, Magdalen Road, Exeter, UK.

Keywords

Adipose Tissue, Humans, Diabetes Mellitus, Type 2, Obesity, Genetic Predisposition to Disease, Birth Weight, Body Mass Index, Case-Control Studies, Cohort Studies, Homozygote, Polymorphism, Single Nucleotide, Alleles, Adolescent, Adult, Aged, Middle Aged, Child, Infant, Newborn, Female, Male, Overweight, United Kingdom