This article describes the impact of sotalol, a Class III anti-arrhythmic that is known to prolong the QT intervaland induce torsades de pointes, on ventricular repolarisation. Timing and T-wave morphology-based biomarkers of ventricular repolarisation are extracted from 24-hour Holter electrocardiogram (ECG) recordings from a clinical sotalol study [1]. The results show sotalol produces a significant dose-dependent increase of QT and T-peak to T-wave end (T pe ) intervals (p < 0.0001). The effect of sotalol tends to significantly increase the morphologybased biomarkers, with the exception of Tarea and T-wave area-based symmetry (T SymA ). The morphology based biomarkers are shown to be more sensitive to the effects of sotalol and the maximum effect on morphology biomarkers tends to take place after the maximum effect on the heart rate, QT and T pe intervals.

Type

Conference paper

Publication Date

01/12/2010

Volume

37

Pages

689 - 692