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Liquid ventilation with perflubron in the treatment of rats with pneumococcal pneumonia.

Dickson EW., Heard SO., Tarara TE., Weers JG., Brueggemann AB., Doern GV.

ObjectiveTo determine the efficacy of liquid ventilation using a medical-grade perfluorocarbon (perflubron) combined with parenteral or intratracheal antibiotics in a rat model of pneumonia.DesignProspective, laboratory investigation.SettingExperimental laboratory in a university medical center.SubjectsWistar rats (n = 112).InterventionsOne day after intratracheal inoculation with Streptococcus pneumoniae, rats received one of five experimental treatments or no treatment (control): modified liquid ventilation (MLV), intramuscular ampicillin, MLV plus intramuscular ampicillin, MLV with intratracheal ampicillin, or MLV plus ampicillin PulmoSpheres.Measurements and main resultsAnimals receiving MLV plus intramuscular ampicillin, MLV with intratracheal ampicillin, or MLV plus ampicillin PulmoSpheres had significantly improved 10-day survival rates (85%, 72%, and 72%, respectively) compared with all other groups (0% to 25%).ConclusionsMLV in combination with either intramuscular, intratracheal, or PulmoSpheres ampicillin improved survival as compared with MLV alone or the same dose of antibiotics delivered intramuscularly.

More information Original publication

DOI

10.1097/00003246-200202000-00021

Type

Journal article

Publication Date

2002-02-01T00:00:00+00:00

Volume

30

Pages

393 - 395

Total pages

2

Addresses

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Keywords

Animals, Rats, Rats, Wistar, Pneumonia, Pneumococcal, Hydrocarbons, Brominated, Fluorocarbons, Anti-Bacterial Agents, Combined Modality Therapy, Liquid Ventilation, Infusions, Parenteral, Statistics, Nonparametric, Survival Analysis, Random Allocation, Male