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Isolates from consecutive Clostridium difficile infection (CDI) fecal samples underwent multilocus sequence typing. Potential reinfections with different genotypes were identified in 88/560 (16%) sample pairs taken 1 to 1,414 days (median, 24; interquartile range [IQR], 1 to 52 days) apart; odds of reinfection increased by 58% for every doubling of time between samples. Of 109 sample pairs taken on the same day, 3 (3%) had different genotypes. Considering samples 0 to 7 days apart as the same CDI, 7% of cases had mixed infections with >1 genotype.

Original publication




Journal article


Journal of clinical microbiology

Publication Date





142 - 144


NIHR Oxford Biomedical Research Centre, John Radcliffe Hospital, Oxford, United Kingdom.


Feces, Humans, Clostridium difficile, Clostridium Infections, Recurrence, Cluster Analysis, Genotype, Molecular Epidemiology, Multilocus Sequence Typing, Coinfection