Computational omics approaches to investigate the potential causal role of sleep and circadian rhythm disturbances in depression
Bian B., Revez JA., Crouse JJ., Hickie IB., Gachon F., Wray NR.
Abstract Hickie et al. (2023) pose the question “Are sleep and circadian rhythm disturbances (SCRD) the cause or simply the consequence of depression or other mood disorder sub-types?” and suggest strategies to better understand the role of SCRD in depression. Here, we contribute to the discussion by highlighting state-of-the-art computational omics methods (and the data sets needed to use these methods) which have potential for improving our understanding of the role of circadian biology in mood disorders.