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ObjectiveThe authors tested for genetic linkage of DSM-IV-diagnosed major depressive disorder in families that were ascertained for cigarette smoking.MethodWithin a study that targeted families characterized by a history of smoking, analyses derived a subset of 91 Australian families with two or more offspring with a history of DSM-IV major depressive disorder (affected sibling pairs, N=187) and 25 Finnish families (affected sibling pairs, N=33). Within this affected sibling pairs design, the authors conducted nonparametric linkage analysis.ResultsIn the Australian heavy smoking families, the authors found a genome-wide significant multipoint LOD score of 4.14 for major depressive disorder on chromosome 3 at 24.9 cM (3p26-3p25).ConclusionsGenome-wide significant linkage was detected for major depressive disorder on chromosome 3p in a sample ascertained for smoking. A linkage peak at this location was also observed in an independent study of major depressive disorder.

Original publication




Journal article


The American journal of psychiatry

Publication Date





848 - 852


Department of Psychiatry, WashingtonUniversity School of Medicine, Saint Louis, MO 63110, USA.


Chromosomes, Human, Pair 3, Humans, Diseases in Twins, Receptors, Metabotropic Glutamate, Smoking, Depressive Disorder, Major, Genotype, Lod Score, Polymorphism, Single Nucleotide, Alleles, Diagnostic and Statistical Manual of Mental Disorders, Adult, Queensland, Finland, Genome-Wide Association Study, Genetic Linkage