Cookies on this website

We use cookies to ensure that we give you the best experience on our website. If you click 'Accept all cookies' we'll assume that you are happy to receive all cookies and you won't see this message again. If you click 'Reject all non-essential cookies' only necessary cookies providing core functionality such as security, network management, and accessibility will be enabled. Click 'Find out more' for information on how to change your cookie settings.

Genetic factors are recognized to contribute to peptic ulcer disease (PUD) and other gastrointestinal diseases, such as gastro-oesophageal reflux disease (GORD), irritable bowel syndrome (IBS) and inflammatory bowel disease (IBD). Here, genome-wide association study (GWAS) analyses based on 456,327 UK Biobank (UKB) individuals identify 8 independent and significant loci for PUD at, or near, genes MUC1, MUC6, FUT2, PSCA, ABO, CDX2, GAST and CCKBR. There are previously established roles in susceptibility to Helicobacter pylori infection, response to counteract infection-related damage, gastric acid secretion or gastrointestinal motility for these genes. Only two associations have been previously reported for duodenal ulcer, here replicated trans-ancestrally. The results highlight the role of host genetic susceptibility to infection. Post-GWAS analyses for PUD, GORD, IBS and IBD add insights into relationships between these gastrointestinal diseases and their relationships with depression, a commonly comorbid disorder.

Original publication




Journal article


Nature communications

Publication Date





Institute for Molecular Bioscience, The University of Queensland, Brisbane, Australia.


Humans, Helicobacter pylori, Helicobacter Infections, Gastrointestinal Diseases, Gastroesophageal Reflux, Inflammatory Bowel Diseases, Peptic Ulcer, Duodenal Ulcer, Genetic Predisposition to Disease, Fucosyltransferases, Galactosyltransferases, Neoplasm Proteins, Antigens, Neoplasm, ABO Blood-Group System, Depression, Female, Male, Mucin-1, Genome-Wide Association Study, Mucin-6, GPI-Linked Proteins, CDX2 Transcription Factor