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Blood pressure (BP) was inconsistently associated with migraine and the mechanisms of BP-lowering medications in migraine prophylaxis are unknown. Leveraging large-scale summary statistics for migraine (Ncases/Ncontrols = 59,674/316,078) and BP (N = 757,601), we find positive genetic correlations of migraine with diastolic BP (DBP, rg = 0.11, P = 3.56 × 10-06) and systolic BP (SBP, rg = 0.06, P = 0.01), but not pulse pressure (PP, rg = -0.01, P = 0.75). Cross-trait meta-analysis reveals 14 shared loci (P ≤ 5 × 10-08), nine of which replicate (P -25) on migraine than SBP (1.05 [1.03-1.07]/10 mmHg; P = 2.60 × 10-07) and a corresponding opposite effect for PP (0.92 [0.88-0.95]/10 mmHg; P = 3.65 × 10-07). These findings support a critical role of DBP in migraine susceptibility and shared biology underlying BP and migraine.

Original publication




Journal article


Nature communications

Publication Date





Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, 02215, USA.


International Headache Genetics Consortium, 23andMe Research Team, Humans, Hypertension, Genetic Predisposition to Disease, Telomerase, Proteins, Receptors, Adrenergic, alpha-2, Integrin beta Chains, Risk Factors, Blood Pressure, Polymorphism, Single Nucleotide, Migraine Disorders, Meta-Analysis as Topic, Genome-Wide Association Study, Mendelian Randomization Analysis