GWAS of Suicide Attempt in Psychiatric Disorders and Association With Major Depression Polygenic Risk Scores.
Mullins N., Bigdeli TB., Børglum AD., Coleman JRI., Demontis D., Mehta D., Power RA., Ripke S., Stahl EA., Starnawska A., Anjorin A., M.R.C.Psych None., Corvin A., Sanders AR., Forstner AJ., Reif A., Koller AC., Świątkowska B., Baune BT., Müller-Myhsok B., Penninx BWJH., Pato C., Zai C., Rujescu D., Hougaard DM., Quested D., Levinson DF., Binder EB., Byrne EM., Agerbo E., Dr.Med.Sc None., Streit F., Mayoral F., Bellivier F., Degenhardt F., Breen G., Morken G., Turecki G., Rouleau GA., Grabe HJ., Völzke H., Jones I., Giegling I., Agartz I., Melle I., Lawrence J., M.R.C.Psych None., Walters JTR., Strohmaier J., Shi J., Hauser J., Biernacka JM., Vincent JB., Kelsoe J., Strauss JS., Lissowska J., Pimm J., M.R.C.Psych None., Smoller JW., Guzman-Parra J., Berger K., Scott LJ., Jones LA., Azevedo MH., Trzaskowski M., Kogevinas M., Rietschel M., Boks M., Ising M., Grigoroiu-Serbanescu M., Hamshere ML., Leboyer M., Frye M., Nöthen MM., Alda M., Preisig M., Nordentoft M., Boehnke M., O'Donovan MC., Owen MJ., Pato MT., Renteria ME., Budde M., Dipl.-Psych None., Weissman MM., Wray NR., Bass N., M.R.C.Psych None., Craddock N., Smeland OB., Andreassen OA., Mors O., Gejman PV., Sklar P., McGrath P., Hoffmann P., McGuffin P., Lee PH., Mortensen PB., Kahn RS., Ophoff RA., Adolfsson R., Van der Auwera S., Djurovic S., Kloiber S., Heilmann-Heimbach S., Jamain S., Hamilton SP., McElroy SL., Lucae S., Cichon S., Schulze TG., Hansen T., Werge T., Air TM., Nimgaonkar V., Appadurai V., Cahn W., Milaneschi Y., Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium None., Bipolar Disorder Working Group of the Psychiatric Genomics Consortium None., Schizophrenia Working Group of the Psychiatric Genomics Consortium None., Fanous AH., Kendler KS., McQuillin A., Lewis CM.
ObjectiveMore than 90% of people who attempt suicide have a psychiatric diagnosis; however, twin and family studies suggest that the genetic etiology of suicide attempt is partially distinct from that of the psychiatric disorders themselves. The authors present the largest genome-wide association study (GWAS) on suicide attempt, using cohorts of individuals with major depressive disorder, bipolar disorder, and schizophrenia from the Psychiatric Genomics Consortium.MethodsThe samples comprised 1,622 suicide attempters and 8,786 nonattempters with major depressive disorder; 3,264 attempters and 5,500 nonattempters with bipolar disorder; and 1,683 attempters and 2,946 nonattempters with schizophrenia. A GWAS on suicide attempt was performed by comparing attempters to nonattempters with each disorder, followed by a meta-analysis across disorders. Polygenic risk scoring was used to investigate the genetic relationship between suicide attempt and the psychiatric disorders.ResultsThree genome-wide significant loci for suicide attempt were found: one associated with suicide attempt in major depressive disorder, one associated with suicide attempt in bipolar disorder, and one in the meta-analysis of suicide attempt in mood disorders. These associations were not replicated in independent mood disorder cohorts from the UK Biobank and iPSYCH. No significant associations were found in the meta-analysis of all three disorders. Polygenic risk scores for major depression were significantly associated with suicide attempt in major depressive disorder (R2=0.25%), bipolar disorder (R2=0.24%), and schizophrenia (R2=0.40%).ConclusionsThis study provides new information on genetic associations and demonstrates that genetic liability for major depression increases risk for suicide attempt across psychiatric disorders. Further collaborative efforts to increase sample size may help to robustly identify genetic associations and provide biological insights into the etiology of suicide attempt.