Dr Emil Jørsboe
Post doctoral researcher
Dr Jørsboe's main research is focused on applying visual deep learning model to histology data to derive biologically relevant phenotypes. Then using statistical methods, to study how these phenotypes associate with genetics or epidemiological data. Emil is currently involved in two projects. The first project is studying adipose tissue histology, the focus is on understanding the genetic basis of adipocyte morphology. The second project is building a model for liver histology samples from non-alcoholic fatty liver disease patients. The aim of the model is to aid pathologists in assessing liver histology samples, giving more accurate and consistent diagnoses.
Dr Jørsboe has a background in statistical and medical genetics, with a PhD from the University of Copenhagen. Emil worked during his PhD with genetic association studies in a Greenlandic cohort, applying statistical models that can take the high degree of relatedness and admixture into account. These results revealed a unique genetic architecture of common variants with large effect-sizes having a large impact on metabolism.
GWAS of lipids in Greenlanders finds association signals shared with Europeans and reveals an independent PCSK9 association signal.
Senftleber NK. et al, (2023), European journal of human genetics : EJHG
A novel splice-affecting HNF1A variant with large population impact on diabetes in Greenland.
Thuesen ACB. et al, (2023), The Lancet regional health. Europe, 24
The effect of sucrase-isomaltase deficiency on metabolism, food intake and preferences: protocol for a dietary intervention study
Senftleber NK. et al, (2023), International Journal of Circumpolar Health, 82
An LDLR missense variant poses high risk of familial hypercholesterolemia in 30% of Greenlanders and offers potential of early cardiovascular disease intervention.
Jørsboe E. et al, (2022), HGG advances, 3
Loss of Sucrase-Isomaltase Function Increases Acetate Levels and Improves Metabolic Health in Greenlandic Cohorts.
Andersen MK. et al, (2022), Gastroenterology, 162, 1171 - 1182.e3