MA BMBCh MRCPsych DPhil
Wellcome Trust CRCD Fellow; Consultant Psychiatrist
I qualified in Medicine from the University of Oxford and subsequently pursued specialist training in older adult psychiatry. In 2017 I completed a DPhil in Psychiatry based on the MRC-funded study "Predicting MRI abnormalities with longitudinal data of the Whitehall II Substudy".
My current research, based in the Neuroimaging Statistics group at the Big Data Institute, uses population neuroimaging to study the impact of risk and resilience factors on psychiatric and cognitive disorders of later life. A particular interest is the association of alcohol consumption, a lifestyle factor which is widespread and modifiable, with adverse brain outcomes including dementia. As a practicing clinician I hope my research will ultimately yield benefits in dementia prevention.
In 2019 I was awarded a Wellcome Trust Clinical Research Career Development Fellowship to investigate the effect of and mechanistic pathways through which alcohol consumption impacts brain health. Using huge databases, which contain lifestyle and clinical data on millions of people in the UK and US, and the largest brain imaging and genetic samples worldwide, I will clarify how alcohol affects brain structure and function. The research will be conducted in collaboration with colleagues at the Universities of Oxford, Yale and London.
My previous funding has been through the MRC, the Ruth and Nevill Mott Scholarship at Linacre College, and grants from Alzheimer's Research UK and the University of Oxford. Prizes awarded include the Gosling Fellowship from the Royal College of Psychiatrists, a Junior Investigator Award from the European Society for Biomedical Research on Alcoholism, and a European Psychiatry Society Research prize.
Topiwala A. et al, (2017), BMJ (Clinical research ed.), 357
Impact of moderate alcohol consumption on brain iron and cognition: observational and genetic analyses
Topiwala A. et al, (2022)
No safe level of alcohol consumption for brain health: observational cohort study of 25,378 UK Biobank participants
Topiwala A. et al, (2021)
Development and Validation of a Novel Dementia Risk Score in the UK Biobank Cohort
Anatürk M. et al, (2021)
Subjective Cognitive Complaints Given in Questionnaire: Relationship With Brain Structure, Cognitive Performance and Self-Reported Depressive Symptoms in a 25-Year Retrospective Cohort Study.
Topiwala A. et al, (2021), The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry, 29, 217 - 226
Association of trajectories of depressive symptoms with vascular risk, cognitive function and adverse brain outcomes: The Whitehall II MRI sub-study.
Demnitz N. et al, (2020), Journal of psychiatric research, 131, 85 - 93