Professor Angela Brueggemann
Professor of Infectious Disease Epidemiology
Angela Brueggemann’s research is focused on understanding bacterial population structure and how changes in that population structure impact on global health and vaccine initiatives. Her research group uses genome sequencing and large collections of bacteria to understand molecular epidemiology and bacterial evolution, especially evolutionary changes related to vaccine selective pressures and antimicrobial resistance.
Angela has a Wellcome Trust Investigator Award to investigate bacteriocins, which are antimicrobial peptides produced by many bacterial species in order to kill other bacteria. Other major research projects relate to bacteriophages, the impact of pneumococcal vaccination, the burden of meningitis in Africa, and making bacterial genome sequence data widely accessible to the international community. She is also involved in outreach activities for school children and is keen to inspire the next generation of scientists.
Angela received her DPhil from the University of Oxford in 2004 and was a Senior Research Fellow in the Department of Public Health and Primary Care from 2001-2005. She was then an Infectious Diseases Lecturer in the Department of Zoology for three years. She was awarded a Wellcome Trust Research Fellowship in 2008 and moved to the Nuffield Department of Medicine in 2013. She moved from Oxford to Imperial College London in 2016 and became a Professor of Infectious Disease Epidemiology in the Department of Medicine. She moved back to Oxford and took up her new post in the Nuffield Department of Population Health in 2019.
Vaccination of Icelandic Children with the 10-Valent Pneumococcal Vaccine Leads to a Significant Herd Effect among Adults in Iceland.
Quirk SJ. et al, (2019), Journal of clinical microbiology, 57
Genomic Analyses of >3,100 Nasopharyngeal Pneumococci Revealed Significant Differences Between Pneumococci Recovered in Four Different Geographical Regions.
van Tonder AJ. et al, (2019), Frontiers in Microbiology, 10
Prophages and satellite prophages are widespread among Streptococcus species and may play a role in pneumococcal pathogenesis
Javan RR. et al, (2018)
Effect of Vaccination on Pneumococci Isolated from the Nasopharynx of Healthy Children and the Middle Ear of Children with Otitis Media in Iceland.
Quirk SJ. et al, (2018), Journal of clinical microbiology, 56
Diverse Streptococcus pneumoniae Strains Drive a Mucosal-Associated Invariant T-Cell Response Through Major Histocompatibility Complex class I-Related Molecule-Dependent and Cytokine-Driven Pathways.
Kurioka A. et al, (2018), The Journal of infectious diseases, 217, 988 - 999