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For the identification of genes associated with smoking initiation and current smoking, genome-wide association analyses were carried out in 3497 subjects. Significant genes that replicated in three independent samples (n = 405, 5810, and 1648) were visualized into a biologically meaningful network showing cellular location and direct interaction of their proteins. Several interesting groups of proteins stood out, including glutamate receptors (e.g., GRIN2B, GRIN2A, GRIK2, GRM8), proteins involved in tyrosine kinase receptor signaling (e.g., NTRK2, GRB14), transporters (e.g., SLC1A2, SLC9A9) and cell-adhesion molecules (e.g., CDH23). We conclude that a network-based genome-wide association approach can identify genes influencing smoking behavior.

Original publication

DOI

10.1016/j.ajhg.2009.02.001

Type

Journal article

Journal

American journal of human genetics

Publication Date

05/03/2009

Volume

84

Pages

367 - 379

Addresses

Department of Biological Psychology, Center for Neurogenomic and Cognitive Research, VU University Amsterdam, The Netherlands. jm.vink@psy.vu.nl

Keywords

Humans, Receptor Protein-Tyrosine Kinases, Cell Adhesion Molecules, Receptors, Glutamate, Smoking, Smoking Cessation, Signal Transduction, Protein Binding, Adult, Middle Aged, Female, Male, Genome-Wide Association Study