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We analyzed the PRNP M129V polymorphism in a Dutch population-based early-onset Alzheimer's disease sample. We observed a significant association between early-onset Alzheimer's disease and homozygosity of M129V (odds ratio [OR], 1.9; 95% confidence interval [CI], 1.1-3.3; p = 0.02) with the highest risk for V homozygotes (OR, 3.2; 95% CI, 1.4-7.1; p < 0.01). In patients with a positive family history, these risks increased to 2.6 (95% CI, 1.3-5.3; p < 0.01) and 3.5 (95% CI, 1.3-9.3; p = 0.01), respectively.

Original publication

DOI

10.1002/ana.10507

Type

Journal article

Journal

Annals of neurology

Publication Date

03/2003

Volume

53

Pages

409 - 412

Addresses

Department of Molecular Genetics, Flanders Interuniversity Institute of Biotechnology (VIB8), University of Antwerp, Antwerpen, Belgium.

Keywords

Humans, Alzheimer Disease, Amyloid, Prions, Protein Precursors, Confidence Intervals, Odds Ratio, Risk Factors, Chi-Square Distribution, Genotype, Homozygote, Alleles, Adult, Aged, Middle Aged, Female, Male, Prion Proteins