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Mutations at codons 717 and 670/671 in the amyloid precursor protein (APP) are rare genetic causes of familial Alzheimer's disease (AD). A mutation at codon 693 of APP has also been described as the genetic defect in hereditary cerebral hemorrhage with amyloidosis of the Dutch type (HCHWA-D). We have reported a APP692Ala-->Gly (Flemish) mutation as a cause of intracerebral hemorrhage and presenile dementia diagnosed as probable AD in a Dutch family. We now describe the post-mortem examination of two demented patients with the APP692 mutation. The neuropathological findings support the diagnosis of AD. Leptomeningial and parenchymal vessels showed extensive deposition of Abeta amyloid protein. Numerous senile plaques consisted of large Abeta amyloid cores, often measuring more than 30 microm in diameter and were surrounded by a fine meshwork of dystrophic neurites. In addition, there were a large number of paired helical filaments in pyramidal neurons and dystrophic neurites. Our findings show that the APP692 mutation leads to morphological abnormalities that are similar to AD, but the morphology of senile plaques is clearly distinct from that described in sporadic and chromosome 14-linked AD patients, in patients with APP717 mutations causing familial, presenile AD and in patients with the APP693 mutation causing HCHWA-D.

Original publication

DOI

10.1007/s004010050892

Type

Journal article

Journal

Acta neuropathologica

Publication Date

09/1998

Volume

96

Pages

253 - 260

Addresses

Laboratory of Neuropathology, Born-Bunge Foundation, University of Antwerp, Wilrijk, Belgium. cras@uia.ua.ac.be

Keywords

Brain, Humans, Cerebral Amyloid Angiopathy, Dementia, Alzheimer Disease, Amyloid, Amyloid beta-Protein Precursor, Microscopy, Electron, Amino Acid Substitution, Cell Size, Mutation, Middle Aged, Female, Male, Plaque, Amyloid