Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

Cathepsin D (CTSD) is a gene involved in amyloid precursor protein processing and is considered a candidate for Alzheimer's disease (AD). The aim of the current study was to examine if variation in CTSD increases the risk of AD. We performed a candidate-gene analysis in a population-based cohort study (N=7983), and estimated the effect of CTSD on the risk of AD. Additionally, a large meta-analysis was performed incorporating our data and previously published data. The T-allele of CTSD rs17571 was associated with an increased risk of AD (p-value 0.007) in the Rotterdam Study. This association was predominantly found in APOE ε4 noncarriers. A meta-analysis of previously published data showed a significantly increased risk of AD in carriers of the T-allele of rs17571 (OR 1.22, 95% CI 1.03-1.44), irrespective of APOE ε4 carrier status. This study adds to the evidence that CTSD increases the risk of AD, although the effect size is moderate.

Original publication

DOI

10.1016/j.neurobiolaging.2009.10.011

Type

Journal article

Journal

Neurobiology of aging

Publication Date

09/2011

Volume

32

Pages

1607 - 1614

Addresses

Genetic Epidemiology Unit of the Department of Epidemiology, Erasmus MC University Medical Center Rotterdam, The Netherlands.

Keywords

Humans, Alzheimer Disease, Genetic Predisposition to Disease, Cathepsin D, Risk Factors, Case-Control Studies, Cohort Studies, Longitudinal Studies, Evidence-Based Medicine, Polymorphism, Single Nucleotide, Aged, Aged, 80 and over, Female, Male