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AIMS: To investigate whether polymorphisms in SLC6A20 are associated with susceptibility to Type 2 diabetes. METHODS: In the Rotterdam Study, a prospective, population-based cohort (n = 5974), 22 tagging polymorphisms with minor allele frequencies>0.05 across SLC6A20 were studied. Replication studies were performed in an independent Dutch case-control study (DiaGene-Rotterdam Study 2 n = 3133), and in a Chinese Han case-control population (n = 2279). A meta-analysis of the results was performed. RESULTS: In the Rotterdam study, the minor alleles of rs13062383, rs10461016 and rs2286489 increased the risk of Type 2 diabetes (hazard ratio 1.37, 95% CI 1.15-1.63, hazard ratio 1.30 95% CI 1.09-1.54 and hazard ratio 1.20, 95% CI 1.07-1.35, respectively). In the DiaGene/Rotterdam Study 2, the A allele of rs13062383 increased the risk of Type 2 diabetes (odds ratio 1.45, 95% CI 1.19-1.76). In the Chinese Han study, the rs13062383 A allele also increased the risk of Type 2 diabetes (odds ratio 1.21, 95% CI 1.03-1.42). Meta-analysis showed a highly significant association of rs13062383 with Type 2 diabetes (odds ratio 1.35, 95% CI 1.21-1.47; P = 3.3 × 10⁻⁸). CONCLUSIONS: In conclusion, rs13062383 in SLC6A20 increased the susceptibility to Type 2 diabetes in populations with different genetic backgrounds.

Original publication

DOI

10.1111/dme.12528

Type

Journal article

Journal

Diabetic medicine : a journal of the British Diabetic Association

Publication Date

11/2014

Volume

31

Pages

1350 - 1356

Addresses

Department of Endocrinology and Metabolism, Zhongshan hospital, Fudan University, Shanghai, China.

Keywords

Humans, Diabetes Mellitus, Type 2, Genetic Predisposition to Disease, Membrane Transport Proteins, Case-Control Studies, Cohort Studies, Follow-Up Studies, Prospective Studies, Gene Frequency, Polymorphism, Single Nucleotide, Alleles, Introns, Adult, Aged, Middle Aged, Asian Continental Ancestry Group, European Continental Ancestry Group, China, Netherlands, Female, Male, Genetic Association Studies