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BACKGROUND: Evidence suggests that the angiotensinogen (AGT) gene is involved in depression. The aim of this paper is to examine the association between the AGT M235T polymorphism and symptoms of depression in two independent populations; a population-based study, and a family-based study. METHODS: Symptoms of depression were scored using the Centre of Epidemiological Studies Depression Scale (CES-D) and compared between the MM, MT, and TT genotype groups. The extent to which AGT M235T explains the heritability of the scores was examined using a variance components analysis. RESULTS: A significant relationship between the AGT M235T polymorphism and CES-D scores was found in men in both populations. The heritability estimate was 32%. The AGT genotype contributed to 1% of the total variance of the CES-D scores. CONCLUSION: Our findings suggest that the AGT gene is involved in the aetiology of symptoms of depression in men.

Original publication

DOI

10.1097/ypg.0b013e3282fb7fd6

Type

Journal article

Journal

Psychiatric genetics

Publication Date

08/2008

Volume

18

Pages

162 - 166

Addresses

Department of Epidemiology and Biostatistics, Erasmus University Medical Center, Rotterdam, The Netherlands.

Keywords

Humans, Genetic Predisposition to Disease, Methionine, Threonine, Angiotensinogen, Antihypertensive Agents, Amino Acid Substitution, Depression, Family, Psychiatric Status Rating Scales, Aging, Gene Frequency, Polymorphism, Single Nucleotide, Aged, Middle Aged, Female, Male