A statistical approach for detecting genomic aberrations in heterogeneous tumor samples from single nucleotide polymorphism genotyping data
Yau C., Mouradov D., Jorissen RN., Colella S., Mirza G., Steers G., Harris A., Ragoussis J., Sieber O., Holmes CC.
ABSTRACT: We describe a statistical method for the characterisation of genomic aberrations in single nucleotide polymorphism microarray data acquired from cancer genomes. Our approach allows us to model the joint effect of polyploidy, normal DNA contamination and intra-tumour heterogeneity within a single unified Bayesian framework. We demonstrate the efficacy of our method on numerous datasets including laboratory generated mixtures of normal-cancer cell lines and real primary tumours.